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A mutation at one base of the first codon of a gene forms a non-functional protein. It is called a:
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Missense mutation
A point mutation in which a change of a single nucleotide results in a codon for a different amino acid is called a missense mutation. Change in the first base of a codon results in a change in the entire codon as genetic code is degenerate in nature. Due to this, the amino acid changes and so does the nature of the entire protein.
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