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A person suffering from a disease caused by Plasmodium, experiences recurring chill and fever at the time when the
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parasite after its rapid multiplication inside RBCs ruptures them, releasing the stage to enter fresh RBCs
In malaria, chill and fever is due to the release of a toxic substance haemozoin, formed by breakdown of haemoglobin present in RBCs. It will be released after the rupture of RBCs in erythrocytic schizogony.
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