Sickle-cell anaemia is related with malaria not to typhoid and person suffering from sickle-cell anaemia are resistant to malarial parasite and RBC of sickle-cell anaemia patients is distored in shape that is not affected by Plasmodium sp. It is known that heterozygotes \( \left(\mathrm{Hb}^{\mathrm{S}} / \mathrm{HB}^{\mathrm{A}}\right) \), having both types of haemoglobin show resistance to malarial infection because the body targets the \( P \). falcipanum infected cells for destruction. In contrast, due to malarial infection individuals homozygous for normal haemoglobin \( \left(\mathrm{Hb}^A / \mathrm{Hb}^{\mathrm{A}}\right) \) suffer