Most commonly abused drugs are opioids, cannabinoids and coca alkaloids. These substances have an addictive nature and are dependence forming. Cannabinoids are a group of chemicals interacting with cannabinoid receptors in the brain. They are obtained from plant Cannabis sativa also known as hemp plant. The mode of intake is either oral or inhalation and have effects n the cardiovascular system of the body. Cocaine or coca alkaloid obtained from coca plant affects the CNS and is commonly called coke or crack and is snorted.