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Question: Answered & Verified by Expert
In a cross between a male and female, both heterozygous for sickle cell anaemia gene, what percentage of the progeny will be diseased?
BiologyPrinciples of Inheritance and VariationNEETNEET 2021
Options:
  • A 50 %
  • B 75 %
  • C 25 %
  • D 100 %
Solution:
2166 Upvotes Verified Answer
The correct answer is: 25 %

Since both the parents are heterozygous for sickle-cell anaemia, i.e., shows sickle-cell trait, they are represented by the symbol HbAHbS. Each parent thus will produce two types of gametes; one having a composition HbA and the other having a composition for sickle cell anaemia as HbS. The progeny cross will be as follows:

Progeny:

  HbA HbS
HbA HbAHbA
(Normal)
HbAHbS
(Sickle-cell trait)
HbS HbAHbS
(Sickle-cell trait)
HbSHbS
(Diseased)

Phenotypic ratio: Normal: Sickle-cell trait: Diseased: 1: 2: 1
Thus, 25% of the progeny will be affected.

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