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In a cross between a male and female, both heterozygous for sickle cell anaemia gene, what percentage of the progeny will be diseased?
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Since both the parents are heterozygous for sickle-cell anaemia, i.e., shows sickle-cell trait, they are represented by the symbol . Each parent thus will produce two types of gametes; one having a composition and the other having a composition for sickle cell anaemia as . The progeny cross will be as follows:
Progeny:
(Normal) | (Sickle-cell trait) | |
(Sickle-cell trait) | (Diseased) |
Phenotypic ratio: Normal: Sickle-cell trait: Diseased:
Thus, of the progeny will be affected.
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