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In leaves of $\mathrm{C}_4$ plants malic acid synthesis during $\mathrm{CO}_2$ fixation occurs in
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mesophyll
In $\mathrm{C}_4$-plants $\mathrm{CO}_2$ combines with phosphoenol pyruvic acid to form oxaloacetic acid in mesophyll chloroplasts. It is further reduced to malic acid which is transferred to chloroplast in bundle sheath cells.
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