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Question: Answered & Verified by Expert
In which disorder change of single base pair in the gene for beta globin chain results in change of glutamic acid to valine?
BiologyPrinciples of Inheritance and VariationNEETNEET 2023 (Manipur)
Options:
  • A Haemophilia
  • B Phenylketonuria
  • C Thalassemia
  • D Sickle cell anaemia
Solution:
2070 Upvotes Verified Answer
The correct answer is: Sickle cell anaemia
Sickle-cell anaemia is caused by mutation of the gene controlling $\beta$-chain of haemoglobin. Due to this mutation, glutamic acid present at $6^{\text {th }}$ position of the $\beta$-chain is replaced by amino acid valine.

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