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Ozone in stratosphere is depleted by
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$\mathrm{CF}_2 \mathrm{Cl}_2$
Ozone depletion is caused by a number of pollutants like chlorofluoro carbons $\left(\mathrm{CF}_2 \mathrm{Cl}_2\right)$ nitrogen oxides, $\mathrm{CCl}_4$ etc.
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