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The most popularly known blood grouping is the $\mathrm{ABO}$ grouping. It is named $\mathrm{ABO}$ and not $A B C$, because ' $O$ ' in it refers to having
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no antigens $A$ and $B$ on RBCs
Landsteiner divided human population into four groups based on the presence of antigens found in their RBCs. Each group represented a blood group. Thus, there are four types of blood groups A, B, AB and O. Blood group ' $O$ ' does not contain any antigen on RBCs, hence can be given to any person, that's why this blood group is called universal donor.
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