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The source of renin in the human kidney is
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Juxta-glomerular cells
JGA (Juxta-glomerular Apparatus): JGA works via Renin-Angiotensin mechanism which works in the following manner:
A. Fall in glomerular blood flow/glomerular blood pressure/GFR Activation of the JG cells Release of Renin in blood.
B. Angiotensinogen Angiotensin I Angiotensin II.
C. Angiotensin II performs 2 functions:
(i) Angiotensin II is a powerful vasoconstrictor Vasoconstriction Glomerular blood pressure increases GFR increases.
(ii) Angiotensin II activates the adrenal cortex Release of Aldosterone Reabsorption of and water from the distal parts of the tubule Increase in blood pressure GFR increases.
A. Fall in glomerular blood flow/glomerular blood pressure/GFR Activation of the JG cells Release of Renin in blood.
B. Angiotensinogen Angiotensin I Angiotensin II.
C. Angiotensin II performs 2 functions:
(i) Angiotensin II is a powerful vasoconstrictor Vasoconstriction Glomerular blood pressure increases GFR increases.
(ii) Angiotensin II activates the adrenal cortex Release of Aldosterone Reabsorption of and water from the distal parts of the tubule Increase in blood pressure GFR increases.
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