Palindrome in DNA is a sequence of base pairs that reads the same on the two strands when the orientation of reading is kept the same. These sequences may range from 4-8 nucleotides in length. For example, the restriction site for EcoRI is between G and A residues in the palindromic sequence given below.

$$\begin{gathered} \downarrow \\ 5\text{'}- GAATTC -3\text{'} \\ 3\text{'}- CTTAAG -5\text{'} \\ \uparrow \end{gathered}$$