«., Sporozoites enter the female Anopheles mosquito when they bite an infected person where these sporozoite fertilise and multiply in the stomach wall of the female Anopheles and get stored in the salivary gland of mosquito till and is again transferred to the human body by a mosquito bite. After it enters the human body the sporozoites reach the liver cells, where they multiply. This is followed by their attack on red blood cells resulting in their rupture. The ruptured RBCs release a toxin called haemozoin, which is responsible for high fever, chills and shivering.