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Question: Answered & Verified by Expert
Which of the following statements is incorrect with respect to sickle cell anaemia?
BiologyPrinciples of Inheritance and VariationNEET
Options:
  • A Homozygous individuals for HbA show the diseased character.
  • B Heterozygous individuals are affected as well as carriers.
  • C Homozygous individuals for HbS remain unaffected.
  • D Homozygous individuals for HbS exhibit sickle cell trait.
Solution:
1422 Upvotes Verified Answer
The correct answer is: Homozygous individuals for HbS exhibit sickle cell trait.
Sickle cell anaemia is an autosomal recessive disease. This disease is controlled by a pair of alleles: HbA (normal dominant allele) and HbS (affected recessive allele).

Both male and female have either of the three genotypes:

1.  HbA HbA: Normal phenotype.

2.  HbA HbS: Normal phenotype.

3.  HbS HbS: Diseased phenotype.

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