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With regard to insulin choose correct options.
(a) C-peptide is not present in mature insulin.
(b) The insulin produced by rDNA technology has C-peptide.
(c) The pro-insulin has C-peptide.
(d) A-peptide and B-peptide of insulin are interconnected by disulphide bridges.
Solution:
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Verified Answer
The correct answer is:
(a), (c) and (d) only
Insulin is a protein hormone that is composed of two chains, an A-chain having amino acids and a B-chain having amino acids, linked together by disulphide bonds (S-S). Insulin is derived from a amino acid prohormone molecule called proinsulin having C-peptide and this is removed before the processing of mature insulin and during the production of recombinant insulin, the two chains were separately produced and then linked with each other. C-peptide is absent in mature insulin.
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