Assertion : Only a boy child could be born with a substitution of glutamic acid by valine on 6 th codon of beta-chain of haemoglobin. Reason : The gene for the above mutation is found on Y-chromosome.

Question

Assertion : Only a boy child could be born with a substitution of glutamic acid by valine on 6 th codon of beta-chain of haemoglobin. Reason : The gene for the above mutation is found on Y-chromosome., If both assertion and reason are true and reason is the correct explanation of assertion., If both assertion and reason are true but reason is not the correct explanation of assertion., If assertion is true but reason is false, If both assertion and reason are false

MARKS App · Accepted Answer

Sickle cell anaemia is an autosomal recessive hereditary disorder in which the erythrocytes become sickle-shaped under oxygen deficiency as during strenuous exercise and at high altitudes. The disorder or disease is caused by the formation of an abnormal haemoglobin called haemoglobin-S. As found out by Ingram (1958), haemoglobin-S differs from normal haemoglobin-A in only one amino acid − 6 th amino acid of β -chain, glutamic acid, is replaced by valine due to substitution (transversion) of T by A in the second position of the triplet codon (CTC) which is changed to CAC in the β -haemoglobin gene situated on chromosome 11.

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