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In the 'S' phase of the cell cycle:
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Amount of DNA doubles in each cell
S-phase/Synthetic phase
(a) DNA replicates and its amount becomes double (2C 4C).
(b) Synthesis of histone proteins.
(c) Euchromatin replicates earlier than heterochromatin.
(d) Synthesis of NHC (non-histone chromosomal proteins).
(e) Each chromosome has 2 chromatids. Amount of DNA doubles but the chromosome number remains constant.
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