Paragraph: $ RCONH 2 is converted into RNH 2 by means of Hofmann bromamide degradation. im g src = " h ttp s : // c d n − q u es t i o n − p oo l . g e t ma r k s . a pp / p y q / j e e a d v an ce d / k Uv d L V ZCCR D n 5 v Z cz 3 o a K 6 c U ZX 7 TS 8 j t 4 M n Q j q I i Z 1 U . or i g ina l . f u ll s i ze . p n g " b r I n t hi sre a c t i o n , R \mathrm{CONHBr}$ is formed from which this reaction has derived its name. Electron donating group at phenyl activates the reaction. Hofmann degradation reaction is an intramolecular reaction. Question: Which is the rate determining step in Hofmann bromamide degradation?

Question

Paragraph: $ RCONH 2 ​ is converted into RNH 2 ​ by means of Hofmann bromamide degradation. im g src = " h ttp s : // c d n − q u es t i o n − p oo l . g e t ma r k s . a pp / p y q / j e e a ​ d v an ce d / k Uv d L V ZCCR D n 5 v Z cz 3 o a K 6 c U ZX 7 TS 8 j t 4 M n Q j q I i Z 1 U . or i g ina l . f u ll s i ze . p n g " > b r > I n t hi sre a c t i o n , R \mathrm{CONHBr}$ is formed from which this reaction has derived its name. Electron donating group at phenyl activates the reaction. Hofmann degradation reaction is an intramolecular reaction. Question: Which is the rate determining step in Hofmann bromamide degradation?, Formation of (i), Formation of (ii), Formation of (iii), Formation of (iv)

MARKS App · Accepted Answer

The rate determining step is probably elimination of Br − to form isocyanate because it is slower step of given conversion.

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