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The oxidative decarboxylation occurs in the step
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-ketoglutarate Succinyl Co-A
α-ketoglutarate undergoes simultaneous dehydrogenation and decarboxylation in the presence of enzyme α-ketoglutarate dehydrogenase complex. This enzyme complex contains TPP, Lipoic Acid, Mg2+, and trans-succinylase. NAD+ and CoA are required. The products formed are 4-carbon compound succinyl CoA, NADH2, and CO2.
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